Joseph M. McClung

This study shows trametinib causes mitochondrial injury and innate immune activation in mouse hearts, leading to cardiomyopathy and heart failure.

This study shows that deleting BAG3 in endothelial cells uniquely alters the proteome of specific organs, with the most significant changes in skeletal muscle.

The paper generates and validates a single-cell RNA-seq dataset to identify pathogenic endothelial metabolism in peripheral arterial disease, showing cell-type specific metabolic changes in CLTI.

This study identifies a bioenergetic mechanism in AML cells where mitochondria consume ATP to resist chemotherapy, offering a target for improving treatment.

The paper identifies a causal network controlling endothelial cell states in critical limb ischemia using transcriptomics data and cSTAR analysis.