Kevin W. Southerland

This study maps endothelial-macrophage interactions in diabetic vasculature using single-cell and spatial transcriptomics, identifying TREM2 as a key driver of vascular inflammation and ischemic response in diabetes.

The paper generates and validates a single-cell RNA-seq dataset to identify pathogenic endothelial metabolism in peripheral arterial disease, showing cell-type specific metabolic changes in CLTI.

The paper identifies Vcam1+ fibro-adipogenic progenitors as markers of fatty infiltration in chronic limb threatening ischemia using single-cell transcriptomics in mouse models.

This study identifies pro-inflammatory macrophages as a key factor impairing skeletal muscle regeneration in ischemic-damaged limbs by inducing premature differentiation of satellite cells.