RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription
Martina Mustè Sadurnì, Megan Louise Jones, Lucas Pavlou, Mohamed Radi, Smaragda Kompocholi, Paolo Passaretti, Agnieszka Gambus, Lea H. Gregersen, Marco Saponaro
The paper shows that overexpression of RNA Polymerase II subunits correlates with poor cancer outcomes and induces genome instability through subunit-specific transcriptional changes.
bioRxiv · Nov 20, 2024 · PreprintMolecular Biology