Author

Marco Saponaro

University of BirminghamORCID 0000-0002-9302-2553Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Daniel HebenstreitiD· 2 shared Jianming WangiD· 2 shared Abeer M. ShaabaniD· 1 shared Agnieszka GambusiD· 1 shared Akhil BowryiD· 1 shared Amber Stiby· 1 shared Anand Kumar SinghiD· 1 shared Ann Liza Piberger· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersMolecular Biology

Daniel HebenstreitORCID

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Author profile →

5 papers

Recent·Most cited

MYBL2 maintains stemness and promotes theta-mediated end joining in triple negative breast cancer

Rachel Bayley, Anna Munsey, Suman Ahmed, Ciara M. Ward, Amber Stiby, Bohdana-Myroslava Briantseva, Kirendeep Jawanda, Abeer M. Shaaban, Marco Saponaro, Graeme C.M. Smith, Robert B. Clarke, Clare C. Davies, Paloma García

This study shows MYBL2 maintains stemness and promotes theta-mediated end joining in TNBC, and identifies Pol{theta}/ATR inhibition as a therapeutic strategy.

bioRxiv · Apr 15, 2025 · PreprintCancer Biology

RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription

Martina Mustè Sadurnì, Megan Louise Jones, Lucas Pavlou, Mohamed Radi, Smaragda Kompocholi, Paolo Passaretti, Agnieszka Gambus, Lea H. Gregersen, Marco Saponaro

The paper shows that overexpression of RNA Polymerase II subunits correlates with poor cancer outcomes and induces genome instability through subunit-specific transcriptional changes.

bioRxiv · Nov 20, 2024 · PreprintMolecular Biology

Genome-wide chromosomal association of Upf1 is linked to Pol II transcription in Schizosaccharomyces pombe

Sandip De, David M. Edwards, Vibha Dwivedi, Jianming Wang, Wazeer Varsally, Hannah L Dixon, Anand Kumar Singh, Precious O. Owuamalam, Matthew T Wright, R. Summers, Md Nazmul Hossain, Emily M Price, Marcin Wlodzimierz Wojewodzic, Francesco Falciani B, Nikolas John Hodges, , Saverio Brogna

This paper reports genome-wide ChIP data showing Upf1 associates with active genes in S. pombe, correlating with Pol II transcription and mRNA levels, and reveals transcriptional defects in Upf1-deficient cells.

Nucleic Acids Research · Dec 6, 2021Peer-reviewedMolecular Biology

RPRD Proteins Control Transcription in Human Cells

Kinga Winczura, Hurmuz Ceylan, Monika Śledziowska, Matt Jones, Holly Fagarasan, Jianming Wang, Marco Saponaro, Roland R. Arnold, Daniel Hebenstreit, Pawel Grzechnik

This study identifies RPRD proteins as negative regulators of transcription in human cells, showing their inverse correlation with RNA accumulation and their role in forming complexes with Pol II.

bioRxiv · Jun 20, 2021 · PreprintMolecular Biology

BET inhibition induces HEXIM1- and RAD51-dependent conflicts between transcription and replication

Akhil Bowry, Ann Liza Piberger, Patricia Rojas, Marco Saponaro, Eva Petermann

This study shows BET inhibition causes replication stress through transcription-replication interference, involving HEXIM1 and RAD51, and reveals a new mechanism for BRD4's role in DNA replication and recombination.

Cell Reports · Nov 1, 2018Peer-reviewedMolecular Biology