Structure-Guided Design and Dynamic Evaluation of VP4-Targeting siRNAs Against Rotavirus A
Abu Nayeem Ahmed, Khaleda Jahan Satu, A.B.Z. Naimur Rahman, SM Sajid Hasan, Mohammad Nazmus Sakib, Md. Ekram Hossan, Arittra Bhattacharjee, Zeshan Mahmud Chowdhury, Ziaul Faruque Joy, Jahirul Islam, Mohammad Uzzal Hossain
The paper designs and evaluates VP4-targeting siRNAs using computational methods to identify an optimized siRNA with improved structural compatibility and stability.
bioRxiv · Apr 4, 2026 · PreprintBioinformatics