Zeshan Mahmud Chowdhury

Structure-Guided Design and Dynamic Evaluation of VP4-Targeting siRNAs Against Rotavirus A

The paper designs and evaluates VP4-targeting siRNAs using computational methods to identify an optimized siRNA with improved structural compatibility and stability.

Linking Genomic Landscape to Disease Mechanism: Core Genetic Factors Underlying Pathogenesis and Antimicrobial Resistance in Diarrheal Pathogens

This study uses whole-genome sequencing and pan-genome analysis of Bangladeshi diarrheal pathogens to identify core genes involved in pathogenesis and antibiotic resistance.

APDeeM: A machine Learning strategy towards Effective Peptide Vaccine Candidates Identification against Different Types of Viruses

The paper introduces APDeeM, an ensemble machine learning system for identifying antiviral peptide candidates, achieving high accuracy and efficiency compared to existing methods.

A meta-analysis of bulk RNA-seq datasets identifies potential biomarkers and repurposable therapeutics against Alzheimers disease

A meta-analysis of bulk RNA-seq datasets identifies 12 differentially expressed genes in Alzheimer's disease, with TTR showing potential as a biomarker and suggesting Levothyroxine as a repurposable therapeutic.

Dissecting Breast Cancer Heterogeneity Through Transcriptomics Insights of Diverse Etiological Factors for Common Biomarker Discovery

The paper identifies shared genes across different breast cancer etiologies and suggests potential therapeutic targets through transcriptomic analysis and computational modeling.

Mapping the PTEN Mutation Landscape: Structural and Functional Drivers of Lung Cancer

The paper identifies fifteen PTEN mutations in lung cancer, seven of which significantly disrupt structure and function, supported by computational analysis and molecular simulations.

AITeQ: A machine learning framework for Alzheimer's prediction using a distinctive 5-gene signature

This paper develops AITeQ, a machine learning framework for Alzheimer's disease prediction using a 5-gene signature identified from RNA-Seq data.

Gut Microbiome Composition Reveals the Distinctiveness between the Bengali people and the Indigenous Ethnicities in Bangladesh

This study compares the gut microbiome of Bengali and indigenous ethnicities in Bangladesh, finding distinct microbial profiles and phylosymbiotic links with Indian groups.

Unraveling Coinfection Dynamics into 100 Whole Genome of Diarrheal Pathogens: A Genome-to-Systems Biology Approach with Plesiomonas shigelloides

This study analyzes 100 whole genomes of diarrheal pathogens, including Plesiomonas shigelloides, to identify coinfection patterns and shared hypothetical proteins with other diarrheal bacteria.

Genome-Wide Exploration of the Opportunistic Providencia stuartii Unveils the Novel Genetic Interactions with the Virulence Gene of Diarrheal Pathogens

This study explores the genetic mechanisms of Providencia stuartii in microbial interactions with diarrheal pathogens and identifies potential therapeutic targets.

From Sequence to Significance: A Thorough Investigation of the Distinctive Genome Traits Uncovered in C. werkmanii strain NIB003

The paper investigates the genomic features of C. werkmanii strain NIB003, identifying antibiotic resistance genes, virulent genes, and genetic variation that may contribute to disease pathogenesis.

A Non-invasive Detection of Parkinson's Disease using PitArray: An Integrative Meta-Analysis and Machine Learning Approach

This study identifies potential biomarkers for Parkinson's disease using blood-based gene expression data and develops a machine learning classifier called PitArray for non-invasive detection.

An Integrated Comparative Genomics, Subtractive Proteomics and Immunoinformatics Framework for the Rational Design of a Pan-Salmonella Multi-Epitope Vaccine

This study designs a pan-Salmonella multi-epitope vaccine using subtractive proteomics and immunoinformatics, identifying CsgA as a conserved vaccine candidate with strong immunogenic properties.

Shotgun metagenomics unravels higher antibiotic resistome profile in Bangladeshi gut microbiome

This study compares antibiotic resistance gene profiles in Bangladeshi gut microbiomes to global samples, finding higher ARG abundance in Bangladeshi cohorts.

Novel Mutations in NSP1 and PLPro of SARS-CoV-2 NIB-1 Genome Mount for Effective Therapeutics

The paper identifies novel mutations in SARS-CoV-2 NIB-1 genome and analyzes their impact on NSP1 and PLPro proteins for therapeutic development.

Whole Genome Sequencing for Revealing the Point Mutations of SARS-CoV-2 Genome in Bangladeshi Isolates and their Structural Effects on Viral Proteins