Optimization and evaluation of complementary degrader discovery assays for application in screening
Johanna Huchting, Arjen Weller, Moyra Schweizer, Mona Brandt, Jan Heering, Maria Kuzikov, Markus Wolf, Jeanette Reinshagen, Markus A. Queisser, Philip M. Gribbon, Andrea Zaliani, Ole Pleß, Aimo Kannt
The paper optimizes and evaluates two cell-based assays for degrader discovery, finding that the signal rescue assay reliably identifies active degraders and filters out non-specific compounds.
ACS Pharmacology & Translational Science · Jul 20, 2025Peer-reviewedPharmacology & Toxicology