Author
Fraunhofer Institute for Translational Medicine and PharmacologyORCID 0000-0002-4922-1993Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Johanna Huchting, Arjen Weller, Moyra Schweizer…·Aimo Kannt
The paper optimizes and evaluates two cell-based assays for degrader discovery, finding that the signal rescue assay reliably identifies active degraders and filters out non-specific compounds.
Julia Schönfeld, Steffen Brunst, Ludmila Ciomirtan…·Kerstin Hiesinger
This paper designs and tests sEH-PROTACs to degrade soluble epoxide hydrolase, identifying PROTAC 23 as effective in degrading sEH in human macrophages.
Sabine Willems, Julian Aurelio Marschner, Whitney Kilu…·Daniel Merk
This study identifies Nurr1 modulation by statins as a mechanism underlying their neuroprotective effects, showing statins affect Nurr1 activity and induce neuroprotective mechanisms.