Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
Tin Long Chris Ng, Mateo P. Hoare, M. Julia Maristany, Ellis J. Wilde, Tomas Sneideris, Jan Huertas, Belinda K. Agbetiameh, Mona Furukawa, Jerelle A. Joseph, Tuomas P. J. Knowles, Rosana Collepardo-Guevara, Laura S. Itzhaki, Janet R. Kumita
This study designs a synthetic biomolecular condensate platform using CTPR proteins and intrinsically-disordered domains to tune condensate properties and recruit target proteins.
bioRxiv · Apr 16, 2024Biophysics