Janet R. Kumita

A live-cell autophagy reporter reveals reversible vacuolation in naked mole-rat skin fibroblasts under lysosomal stress

This study uses a live-cell autophagy reporter to show that naked mole-rat skin fibroblasts form reversible vacuoles under lysosomal stress, indicating dynamic lysosomal remodelling.

Small Molecule Activators of Protein Phosphatase 2A Exert Global Stabilising Effects on the Scaffold PR65

The paper investigates how two small molecule activators of PP2A, ATUX-8385 and DBK-776, affect the structural stability of the PR65 scaffold using biophysical and computational methods.

Amyloid forming human lysozyme intermediates are stabilised by non-native amide-π interactions

This study identifies non-native amide-π interactions stabilizing a transient intermediate state in amyloid-forming human lysozyme using NMR and MD simulations.

Using a stable protein scaffold to display peptides that bind to alpha-synuclein fibrils

The paper demonstrates that stable CTPR proteins can be modified to bind alpha-synuclein fibrils with micromolar affinity, enabling the testing of fibril-binding peptides.

Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates

This study designs a synthetic biomolecular condensate platform using CTPR proteins and intrinsically-disordered domains to tune condensate properties and recruit target proteins.