Jerelle A. Joseph

This study introduces TRACE, a computational model to simulate molecular transport through biomolecular condensates, revealing how sequence composition, molecule stiffness, and host-guest interactions influence flux.

The paper identifies an ABC transporter for xyloglucan uptake in Anaerocellum bescii and solves its substrate-binding protein structure, revealing a unique mode of xyloglucan recognition.

This study shows that the 2'-OH group of RNA influences phase separation and percolation transitions in the presence of Mg2+ ions, with 2-deoxyribose and 2-O-methylation altering these processes.

The paper demonstrates that synthetic membrane-associated condensates (sMACs) can be engineered to enhance metabolic functions by creating localized redox microenvironments through cofactor partitioning.

This study investigates how protein folding landscapes change within biomolecular condensates using atomistic simulations and Bayesian optimization models, revealing sequence-dependent folding behavior influenced by multivalent interactions and crowding.

This study identifies a sequence-encoded mechanism in plant proteins that enables thermoresponsive phase separation through low-complexity domains.

This study identifies an ABC transporter in Anaerocellum bescii responsible for cello-oligosaccharide uptake, showing genetic deletion impairs growth on cellulose and cellobiose.

This paper uses molecular dynamics simulations to show how viscoelastic properties of biomolecular condensates depend on sequence-dependent timescale ratios of shape memory and mesh reconfiguration.

This paper introduces Mpipi-T, a model predicting LCST-type phase behavior of proteins and provides insights into heat stress responses.

This study predicts small-molecule partitioning into biomolecular condensates using atomistic simulations and develops models to guide therapeutic design.

This paper identifies and characterizes two maltodextrin ABC transporters in Anaerocellum bescii, revealing their substrate specificity and biophysical properties to enhance understanding of oligosaccharide transport in thermophilic bacteria.

This study links molecular properties of LCDs to condensate microstructure and macroscopic material properties using simulations and graph analysis.

This study designs a synthetic biomolecular condensate platform using CTPR proteins and intrinsically-disordered domains to tune condensate properties and recruit target proteins.

The paper investigates how RNA-RNA interactions in viral replication are controlled by biomolecular condensates, showing that sequence complementarity and condensate properties influence RNA organization.

This study uses a coarse-grained model to simulate RNA repeat clustering, finding that base pairing and entropy drive cluster formation and that odd repeats cluster more strongly than even repeats.