All-trans retinoic acid recalibrates macrophage transcriptional responses to drug-resistant Mycobacterium tuberculosis through strain-specific immunometabolic reprogramming
Mona Roshan Singh, Rosha Kumar, Shailly Anand, Isha Pahuja, Md. Arafat Hussain, Roushan Kumar, Archana Singh, Ved Prakash Dwivedi, Manoj Kumar, Akinyemi I. Ojesina, Indrakant Kumar Singh
This study investigates how all-trans retinoic acid (ATRA) affects macrophage gene expression in response to different drug-resistant Mycobacterium tuberculosis strains, revealing strain-specific transcriptional changes and potential therapeutic targets.
bioRxiv · Apr 2, 2026 · PreprintMicrobiology