Ligation-assisted target recycling for DNA nanoswitch biosensors
Vinod Morya, Andrew Hayden, Mona Zeghal, Jibin Abraham Punnoose, Ken Halvorsen
This paper introduces a method to enhance DNA nanoswitch biosensor sensitivity by recycling targets through enzymatic ligation and cyclic annealing, enabling signal amplification without target amplification.
bioRxiv · May 20, 2026 · PreprintBiochemistry