Jibin Abraham Punnoose

This paper introduces a method to enhance DNA nanoswitch biosensor sensitivity by recycling targets through enzymatic ligation and cyclic annealing, enabling signal amplification without target amplification.

This study investigates how DNA strand polarity affects base-stacking energetics using single-molecule and computational methods, finding polarity-dependent stability differences in purine-purine and purine-pyrimidine interactions.

This study investigates how base-stacking interactions affect the stability of DNA tetrahedra by testing 16 designs, finding that altering a single base stack can change melting temperatures by up to 10°C.

This paper introduces a Wi-Fi-enabled Centrifuge Force Microscope (CFM) for accessible single-molecule experiments, demonstrating its use in analyzing DNA duplex dissociation kinetics.