Ken Halvorsen

This paper presents a 3D-printed mini-gel electrophoresis system for DNA nanoswitch biosensing, achieving rapid, low-cost, and portable detection of target molecules.

This paper introduces a method to enhance DNA nanoswitch biosensor sensitivity by recycling targets through enzymatic ligation and cyclic annealing, enabling signal amplification without target amplification.

The paper develops aptamer-based DNA nanoswitches for detecting proteins, demonstrating dual detection of thrombin and VEGF.

This study investigates how DNA strand polarity affects base-stacking energetics using single-molecule and computational methods, finding polarity-dependent stability differences in purine-purine and purine-pyrimidine interactions.

This study shows that metal ions and temperature affect DNA nanostructure self-assembly, with divalent ions enabling assembly at lower temperatures and no adverse effects on cell viability.

This study investigates how base-stacking interactions affect the stability of DNA tetrahedra by testing 16 designs, finding that altering a single base stack can change melting temperatures by up to 10°C.

This study examines how the size of DNA tetrahedra affects their biostability, showing nuclease-specific degradation patterns.

This paper introduces a Wi-Fi-enabled Centrifuge Force Microscope (CFM) for accessible single-molecule experiments, demonstrating its use in analyzing DNA duplex dissociation kinetics.

This paper introduces a method using DNA nanoswitches to purify specific RNA species and validates its effectiveness with microRNA, rRNA, and mRNA fragments.