Mesenchymal expression of activated K-ras yields Noonan Syndrome-like bone defects that are rescued by mid-gestational MEK inhibition.
Simona Nedelcu, Tatsuya Kobayashi, Monica Stanciu, Henry M. Kronenberg, Jacqueline A. Lees
This paper generates a mouse model with activated K-ras in mesenchymal progenitors to study Noonan Syndrome-like bone defects and shows that MEK inhibition during mid-gestation rescues these defects.
bioRxiv · May 10, 2019 · PreprintDevelopmental Biology