Henry M. Kronenberg

This study shows intermittent parathyroid hormone drives osteogenesis from Ebf3-expressing progenitors via both intrinsic and extrinsic mechanisms in mice and humans.

This study shows that inducible PKA activation in osteoblasts leads to high bone turnover and disease-like phenotypes in mice.

This study identifies Sp7 and its target gene osteocrin as critical for osteocyte dendrite formation and shows their role in human skeletal diseases.

The paper identifies a Wnt-inhibitory environment maintaining resting zone chondrocytes and shows that Wnt activation disrupts their differentiation into columnar chondrocytes.

The paper links GWAS height loci to genes specifically expressed in the round cell layer of the growth plate, showing significant associations after conditioning on other layers and known skeletal disorder genes.

This paper generates a mouse model with activated K-ras in mesenchymal progenitors to study Noonan Syndrome-like bone defects and shows that MEK inhibition during mid-gestation rescues these defects.