Jacqueline A. Lees

PRMT5 inhibition induces a histone methylation switch that drives chromatin plasticity, drug resistance, and metastatic progression

This study shows PRMT5 inhibition causes splicing defects and epigenetic changes leading to drug resistance and metastatic progression in lung adenocarcinoma.

Primary cilia promote EMT-induced triple-negative breast tumor heterogeneity and resistance to therapy

This study shows primary cilia in TNBC cells contribute to chemoresistance by supporting EMT-driven heterogeneity and stemness, and inhibiting ciliogenesis reduces this resistance.

The PRMT5-splicing axis is a critical oncogenic vulnerability that regulates detained intron splicing

The paper identifies PRMT5 inhibition as inducing detained introns and shows their role in cancer vulnerability through conserved gene regulation across species.

Mesenchymal expression of activated K-ras yields Noonan Syndrome-like bone defects that are rescued by mid-gestational MEK inhibition.

This paper generates a mouse model with activated K-ras in mesenchymal progenitors to study Noonan Syndrome-like bone defects and shows that MEK inhibition during mid-gestation rescues these defects.