Early Insulin Signaling Defects and Oxidative Stress Kinase Activation Precede Tau Pathology in PS19 Tau Transgenic Mice
Montasir Elahi, Irina D. Burd, Peixin Yang, Wei‐Bin Shen
bioRxiv · Oct 24, 2026 · PreprintNeuroscience
Author
Montasir Elahi
University of Maryland, BaltimorePrimary ORCID profile (0000-0002-6201-290X · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints
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Biology Disciplines
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2021-2026 · peak 1/yrCo-Author Collaboration Network
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Recent·Most cited
High-fat diet-induced activation of SGK1 promotes Alzheimer's disease-associated tau pathology
Montasir Elahi, Yumiko Motoi, Shotaro Shimonaka, Yoko Ishida, Hiroyuki Hioki, Masashi Takanashi, Koichi Ishiguro, Yuzuru Imai, Nobutaka Hattori
This study shows that high-fat diet-induced activation of SGK1 promotes tau pathology in Alzheimer's disease by phosphorylating tau and activating GSK-3β.
Human Molecular Genetics · Apr 19, 2021Peer-reviewedNeuroscience