Hiroyuki Hioki

The paper reconstructs growth cones of callosal projection neurons in the developing mouse brain and finds they have a planar, dorsoventrally oriented morphology with filopodia that precede accelerated axon growth.

This study shows that cholinergic modulation between brain hemispheres enables paw preference switching in mice through experience-driven changes in neural activity.

This paper introduces OxyBLI, a noninvasive optical method to monitor tissue oxygenation in real-time, showing how hypoxia and hyperoxia affect oxygen distribution in experimental animals.

The paper evaluates the immunohistochemical reactivity of three anti-Aβ antibodies in AD mouse models, finding significant differences in staining patterns and suggesting antibody-specific effects beyond sensitivity.

This paper introduces a 3D immunolabeling method for high-speed and high-sensitive detection of targets in 3D tissues, demonstrating its application in visualizing neuronal and glial cells in mouse brain tissues.

This study investigates sleep homeostasis in lizards, finding a rebound in local field potential after sleep deprivation and a role for the cortex in regulating sleep-related activity rebounds.

This paper introduces a synthetic near-infrared luciferin, AkaSuke, that enhances deep-tissue bioluminescence imaging with firefly luciferases by improving detection sensitivity.

The paper identifies plaque-associated endogenous IgG in AD mouse models that interferes with immunohistochemical detection of mouse monoclonal IgG antibodies and shows that subclass-specific secondary antibodies can mitigate this issue.

FT-GO improves fluorescent histochemical analysis by enhancing signal detection while reducing background noise in mouse and marmoset brains.

This paper develops a multi-scale neuronal imaging technique combining light and electron microscopy with a tissue clearing method to study brain-wide connectivity across multiple spatial scales.

This study shows that high-fat diet-induced activation of SGK1 promotes tau pathology in Alzheimer's disease by phosphorylating tau and activating GSK-3β.

The paper introduces FASHIO-2PM, a two-photon microscope that enables fast, aberration-free calcium imaging of large neural networks in awake mice at 7.5 Hz.

This study identifies GABAergic dysfunction in the anterior cingulate cortex as a mechanism underlying social deficits caused by maternal immune activation in mice.