SCAD Delivery Platform: A Novel Approach for Efficient CNS and Extrahepatic Oligonucleotide Therapeutics
Moorim Kang, Wei-Hsiang Lin, Feifei Xu, Xiaojie Zhou, Chunyan Si, Kunshan Liu, Jian Dai, J. He, Ian Schacht, Yichen Li, Zubao Gan, Long‐Cheng Li
The paper introduces the SCAD platform for efficient delivery of duplex RNA therapeutics to the CNS and other tissues, showing sustained knockdown and safety in rodent models.
bioRxiv · Oct 29, 2024 · PreprintNeuroscience