G-Quadruplex and i-Motif Structures in the SHMT1 5UTR Modulate Gene Expression
Rosalia M. Palumbo, Manju Kasaju, Sophia C Hershey, Morgan E. McCann, Zoe H Woon, David B. Heisler, Mihaela‐Rita Mihailescu
The paper identifies G-quadruplex and i-motif structures in SHMT1 5UTR that regulate gene expression, suggesting potential therapeutic targets for multiple sclerosis.
bioRxiv · Nov 24, 2025 · PreprintBiochemistry