RF-SIRF defining reversed DNA replication forks with single-cell and spatio-temporal resolution reveals a replication stress specific epigenetic code
Sunetra Roy, Morgan Fimreite, Yue Chen, Francesca Citron, Giulio Francesco Draetta, Katharina Schlacher
The paper introduces RF-SIRF, a method to measure reversed DNA replication forks with single-cell and spatio-temporal resolution, revealing their accumulation at the nuclear periphery and an epigenetic code for replication stress.
bioRxiv · Apr 21, 2025 · PreprintMolecular Biology