Giulio Francesco Draetta

This study identifies the YAP1-SDC1 axis as a driver of resistance to mKRAS inhibitors in gastrointestinal cancers and suggests targeting this axis to overcome resistance.

The paper introduces RF-SIRF, a method to measure reversed DNA replication forks with single-cell and spatio-temporal resolution, revealing their accumulation at the nuclear periphery and an epigenetic code for replication stress.

This study shows that disrupting the WRAD core in pancreatic cancer leads to DNA replication errors, immune response activation, and improved response to immune checkpoint inhibitors.

The paper develops a multiplexed CRISPR/Cas9-based screening strategy using AsCpf1 to create a smaller, more efficient genome-wide knockout library.