Katharina Schlacher

This study reveals how the BRCA2 C-terminal domain reshapes RAD51 dimers to bind B-DNA, promoting replication fork stability over homology-directed repair.

The paper introduces RF-SIRF, a method to measure reversed DNA replication forks with single-cell and spatio-temporal resolution, revealing their accumulation at the nuclear periphery and an epigenetic code for replication stress.

This study identifies diet-induced mitochondrial DNA replication instability in Rad51c mutant mice as a molecular cause of sex-bias in anemia of inflammation, showing estrogen protects females by reducing oxidative stress.

This study identifies p53's role in suppressing mutagenic DNA repair pathways by regulating replication restart, revealing its importance in genomic stability and cancer therapy resistance.