Decoupling of spontaneous and evoked activity in locus coeruleus neurons: early synaptic and ion-channel remodeling in a mouse model of Alzheimer's disease
Baizhen Zhao, Morgan Li, Lingxiao Yi, Jiali Li
This study identifies synaptic and ion-channel remodeling in locus coeruleus neurons of young 3xTg mice, leading to decoupling of spontaneous and evoked activity in a mouse model of Alzheimer's disease.
bioRxiv · Oct 15, 2026 · PreprintNeuroscience