Jiali Li

Decoupling of spontaneous and evoked activity in locus coeruleus neurons: early synaptic and ion-channel remodeling in a mouse model of Alzheimer's disease

This study identifies synaptic and ion-channel remodeling in locus coeruleus neurons of young 3xTg mice, leading to decoupling of spontaneous and evoked activity in a mouse model of Alzheimer's disease.

The mtDNA-derived lncMtDloop promotes mitochondrial homeostasis maintenance and implications in AD

This study identifies lncMtDloop as a regulator of mitochondrial homeostasis, showing reduced expression in AD and improved pathology with its overexpression.

New tree shrew Parkinson's model: a cost-effective alternative to monkey models

This paper develops a tree shrew Parkinson's disease model that replicates key clinical and pathological features of PD, offering a cost-effective alternative to primate models.

ADAM10- and presenilin 1/γ-secretase-dependent cleavage of PTPRT mitigates neurodegeneration of Alzheimer's disease

The paper identifies that cleavage of PTPRT by ADAM10 and presenilin 1/γ-secretase produces PICD, which reduces neurodegeneration in Alzheimer's disease by modulating STAT3 and Aβ.

Novel immune and stromal subtype classification system of lung adenocarcinoma based on tumor microenvironment

The paper develops a PMBT system to classify lung adenocarcinoma into four subtypes based on immune and stromal features, showing distinct molecular, cellular, and prognostic characteristics.