Polyglutamine expansion induced dynamic misfolding of Androgen Receptor
Laurens W.H.J. Heling, Vahid Sheikhhassani, Julian Ng, Morris van Vliet, Alba Jiménez‐Panizo, Andrea Alegre‐Martí, Jaie C. Woodard, Willeke van Roon‐Mom, Iain J. McEwan, Eva Estébanez‐Perpiñá, Alireza Mashaghi
This study uses computational modeling to show that polyglutamine expansion in the androgen receptor's N-terminal domain causes dynamic misfolding, altering interdomain interactions and potentially leading to SBMA pathology.
Protein Science · May 15, 2025Peer-reviewedPathology