Author
Leiden University Medical CenterORCID 0000-0002-3035-0533Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
Recent·Most cited
Laurens R. ter Haar, Sabine de Lange, Dennis Gravekamp, Annick R Kooij, Jasper W. de Wolf, Yanniek Asschert, Timo Oosenbrug, Maarten W. Paul, Peter A. van Veelen, Willeke M.C. van Roon-Mom, Hailiang Mei, Annemarthe G. Van der Veen
This study identifies a noncanonical role for Dicer in regulating self-dsRNA sensing and innate immune responses to self-derived double-stranded RNA.
bioRxiv · Nov 3, 2026 · PreprintImmunology
Elsa C. Kuijper, Linda van der Graaf, Barry A. Pepers, Mariana Guimarães Ramos, Sylvia Korhorn, Lodewijk J.A. Toonen, Davy Cats, Ronald A.M. Buijsen, Eleni Mina, Hailiang Mei, Willeke van Roon‐Mom
This study uses RNAseq to assess off-target effects of three splice-switching AONs in human cells, identifying splicing changes and showing variability in AON-induced effects.
Human Molecular Genetics · Sep 23, 2025Peer-reviewedGenetics
Laurens W.H.J. Heling, Vahid Sheikhhassani, Julian Ng, Morris van Vliet, Alba Jiménez‐Panizo, Andrea Alegre‐Martí, Jaie C. Woodard, Willeke van Roon‐Mom, Iain J. McEwan, Eva Estébanez‐Perpiñá, Alireza Mashaghi
This study uses computational modeling to show that polyglutamine expansion in the androgen receptor's N-terminal domain causes dynamic misfolding, altering interdomain interactions and potentially leading to SBMA pathology.
Protein Science · May 15, 2025Peer-reviewedPathology
Sunniva M. K. Bøstrand, Luise A. Seeker, Nadine Bestard-Cuche, Nina-Lydia Kazakou, Sarah Jäkel, Boyd Kenkhuis, Neil Cowan Henderson, Susanne Tamara de Bot, Willeke van Roon‐Mom, Josef Priller, Anna Williams
This study uses snRNAseq to analyze glial cell heterogeneity in Huntington's disease across brain regions, identifying subtype-specific changes and potential mechanisms of glial dysfunction.
Acta Neuropathologica Communications · Oct 20, 2024Peer-reviewedNeuroscience
Boyd Kenkhuis, Antonios Somarakis, Lynn R.T. Kleindouwel, Willeke van Roon‐Mom, Thomas Höllt, Louise van der Weerd
The paper analyzes the co-expression patterns of Iba1, TMEM119, and P2RY12 in microglia from Alzheimer's patients and controls, finding differences in marker combinations associated with disease pathology.
Neurobiology of Disease · Mar 2, 2022Peer-reviewedNeuroscience
Boyd Kenkhuis, Antonios Somarakis, Lorraine M. de Haan, Oleh Dzyubachyk, Marieke E. Ijsselsteijn, Noel F.C.C. de Miranda, Boudewijn P. F. Lelieveldt, Jouke Dijkstra, Willeke van Roon‐Mom, Thomas Höllt, Louise van der Weerd
The paper identifies iron-accumulating microglia in Alzheimer's brains, linking iron uptake to microglial activation and disease pathology.
Acta Neuropathologica Communications · Feb 17, 2021Peer-reviewedNeuroscience
Chiara Milanese, César Payán‐Gómez, Marta Galvani, Nicolás Molano González, Maria Tresini, Soraya Nait Abdellah, Willeke van Roon‐Mom, Silvia Figini, Johan Marinus, Jacobus Johannes van Hilten, Pier G. Mastroberardino
The paper correlates peripheral mitochondrial function with clinical severity in idiopathic Parkinson’s disease, finding stronger correlations with non-dopaminergic signs and reversible mitochondrial defects under metabolic stress.
Movement Disorders · May 28, 2019Peer-reviewedNeuroscience