Feedback from the Nascent Chain Triggers Ribosomal Frameshifting and Transcript Decay
Patrick J. Carmody, Caden R Sillman, Dyotima Dyotima, Rohan Bhardwaj, Ali Farzam, Morvarid Golrokhmofrad, Braden Lewis, Wesley D. Penn, Bryon Drown, Charles P. Kuntz, Jonathan P. Schlebach
The paper shows that nascent polypeptide feedback triggers ribosomal frameshifting and transcript decay through specific motifs and splicing events.
bioRxiv · Dec 26, 2025 · PreprintBiochemistry