Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections
Ronni A. G. da Silva, Brenda Yin Qi Tien, Patrick Hsien Neng Kao, Haris Antypas, Cenk Celik, Ai Zhu Casandra Tan, Muhammad Hafiz Ismail, Guangan Hu, Kelvin Kian Long Chong, Guillaume Thibault, Jianzhu Chen, Kimberly A. Kline
This paper shows that E. faecalis uses lactic acid to suppress macrophage activation, enabling persistent and polymicrobial wound infections.
Cell Host & Microbe · Jan 27, 2026Peer-reviewedMicrobiology