Kimberly A. Kline

A chaperone-guided donor-strand exchange pathway assembles a Gram-positive pilus

This study identifies a chaperone-guided donor-strand exchange pathway in Enterococcus faecalis that assembles a Gram-positive pilus, revealing a hybrid system combining chaperone-usher and sortase-dependent mechanisms.

Growth-dependent tRNA Reprogramming and Codon Bias Link Translation to Metabolic State in Enterococcus faecalis

This study examines how tRNA reprogramming and codon bias link translation to metabolic state in Enterococcus faecalis across growth phases.

Enterococcus faecalis biofilm rewires neutrophil metabolism to suppress antimicrobial activity

This study shows E. faecalis biofilms suppress neutrophil defenses by producing lactic acid and high bacterial density.

Enterococcus faecalis alters antibiotic susceptibility in Pseudomonas aeruginosa mixed species biofilms.

This study shows that Enterococcus faecalis increases antibiotic resistance in Pseudomonas aeruginosa within iron-limited biofilms by inducing specific transcriptional changes.

Enterococcus faecium colonization and persistence in a model of diabetic wound infection

This study uses a diabetic mouse model to show that Enterococcus faecium persists in wounds due to impaired clearance and altered immune responses compared to non-diabetic mice.

A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin

This study identifies a two-component system signaling hub that controls membrane remodeling in Enterococcus faecalis in response to daptomycin, linking lipid changes to antibiotic resistance.

Gelatinase regulates the egress of intracellular replicating populations during Enterococcus faecalis infection

This study identifies gelatinase as a key factor enabling Enterococcus faecalis to transition from intracellular replication to extracellular egress during infection.

Adaptation of Enterococcus faecalis to intestinal mucus revealed by a human colonic organoid model

This study uses human colonic organoids to reveal how Enterococcus faecalis adapts to intestinal mucus, identifying key fitness determinants and colonization strategies not observed in vitro or in vivo.

Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections

This paper shows that E. faecalis uses lactic acid to suppress macrophage activation, enabling persistent and polymicrobial wound infections.

Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing

This study identifies E. faecalis extracellular electron transport as a source of ROS that triggers the UPR in epithelial cells, impairing wound healing.

Fsr quorum sensing system restricts biofilm growth and activates inflammation in enterococcal infective endocarditis

This study identifies the Fsr quorum sensing system in Enterococcus faecalis as a negative regulator of biofilm growth and inflammation in infective endocarditis.

Enterococcus faecalis persists and replicates intracellularly within neutrophils

This study shows Enterococcus faecalis persists and replicates intracellularly within neutrophils, prolonging infection and inflammation in chronic wounds.

Synergistic cross-kingdom host cell damage between Candida albicans and Enterococcus faecalis

This study shows that Candida albicans and Enterococcus faecalis synergistically increase host cell damage through physical interaction and glucose depletion.

A bioluminescence-based chemical screen identifies a bactericidal naphthalene scaffold targeting MmpL3 in Mycobacterium abscessus

Role of sortase-assembled Ebp pili in Enterococcus faecalis adhesion to iron oxides and its impact on extracellular electron transfer

This study shows Ebp pili in Enterococcus faecalis facilitate adhesion to iron oxides, enhancing extracellular electron transfer and supporting anaerobic growth and colonization in mice.

Streptolysin-induced endoplasmic reticulum stress promotes group A streptococcal in vivo biofilm formation and necrotizing fasciitis

This study identifies streptolysin-induced endoplasmic reticulum stress as a driver of GAS biofilm formation and necrotizing fasciitis progression using in vitro and in vivo models.