Single cell RNA-seq reveals protracted germ line X chromosome reactivation dynamics directed by a PRC2 dependent mechanism
Yaqiong Liu, Xianzhong Lau, Munusamy Prabhakaran, Carlos M Abascal Sherwell Sanchez, Daniel M. Snell, Mahesh N. Sangrithi
The paper uses single-cell RNA-seq and chromatin profiling to study X chromosome reactivation dynamics in mouse germ cells, showing gradual reactivation and PRC2-dependent regulation.
bioRxiv · Nov 6, 2023 · PreprintDevelopmental Biology