Daniel M. Snell

Genome editing of marsupial RSX reveals conserved and divergent principles in mammalian X-inactivation

This study uses CRISPR-Cas9 in opossums to show RSX is required for initiating X-inactivation, with divergent Polycomb regulation compared to eutherians.

Autoantibody origins in lupus and in relapse post CAR-T therapy

The paper shows that autoantibody production in lupus is sustained by continuous B cell differentiation, not long-lived plasma cells, and relapse after CAR-T therapy occurs via new B cells.

SLFN11 restricts escape from telomere crisis to prevent alternative lengthening of telomeres

This paper identifies SLFN11's role in preventing alternative lengthening of telomeres by eliminating ATRX-deficient cells during telomere crisis, contributing to chemoresistance in cancer.

Sex chromosomes shape the transcriptional landscape of the preimplantation mouseembryo

This study shows sex chromosomes significantly shape the transcriptional landscape of preimplantation mouse embryos through various mechanisms including Y chromosome effects, X chromosome dosage, imprinting, and Xist.

Single cell RNA-seq reveals protracted germ line X chromosome reactivation dynamics directed by a PRC2 dependent mechanism

The paper uses single-cell RNA-seq and chromatin profiling to study X chromosome reactivation dynamics in mouse germ cells, showing gradual reactivation and PRC2-dependent regulation.

Deep dynamical modelling of developmental trajectories with temporal transcriptomics

The paper introduces a deep learning framework called velvet to model gene expression dynamics from single-cell data, outperforming existing methods and capturing developmental decision-making processes.

Generating single-sex litters: development of CRISPR-Cas9 genetic tools to produce all-male offspring

The paper develops CRISPR-Cas9 tools to generate all-male mouse litters by targeting the Topoisomerase 1 gene with a bicomponent system.