Mutational scanning of TnpB reveals latent activity for genome editing
Brittney W. Thornton, Rachel F. Weissman, Jorge E. Rodriguez, Ryan V. Tran, Bao Chau Duong, Cynthia I. Terrace, Ugrappa Nagalakshmi, George Austin, Evan D. Groover, Flora Zhiqi Wang, Jung-Un Park, Viktoriya Georgieva, Julia Tartaglia, Myeong-Je Cho, Savithramma P. Dinesh-Kumar, , David F. Savage
This study identifies activating mutations in TnpB enzymes that enhance genome editing activity across multiple species.
bioRxiv · Feb 11, 2025 · PreprintMolecular Biology