Author

Jung-Un Park

Cornell UniversityORCID 0000-0002-0269-7142Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Organism:human· 1 Organism:plant (other)· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Elizabeth H. KelloggiD· 2 shared Ailong KeiD· 1 shared Amy Wei-Lun TsaiiD· 1 shared Bao Chau DuongiD· 1 shared Brittney W. ThorntoniD· 1 shared Christopher AcreeiD· 1 shared Cynthia I. TerraceiD· 1 shared David F. SavageiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMolecular Biology

Elizabeth H. KelloggORCID

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Author profile →

3 papers

Recent·Most cited

Mutational scanning of TnpB reveals latent activity for genome editing

Brittney W. Thornton, Rachel F. Weissman, Jorge E. Rodriguez, Ryan V. Tran, Bao Chau Duong, Cynthia I. Terrace, Ugrappa Nagalakshmi, George Austin, Evan D. Groover, Flora Zhiqi Wang, Jung-Un Park, Viktoriya Georgieva, Julia Tartaglia, Myeong-Je Cho, Savithramma P. Dinesh-Kumar, , David F. Savage

This study identifies activating mutations in TnpB enzymes that enhance genome editing activity across multiple species.

bioRxiv · Feb 11, 2025 · PreprintMolecular Biology

Mechanism of target site selection by type V-K CRISPR-associated transposases

Jerrin Thomas George, Christopher Acree, Jung-Un Park, Muwen Kong, Tanner Wiegand, Yanis Luca Pignot, Elizabeth H. Kellogg, Eric C. Greene, Samuel H. Sternberg

This study identifies two mobilization pathways in type V-K CASTs and shows how manipulating TnsC availability can increase their specificity to 98.1%.

Science · Nov 16, 2023Peer-reviewedMolecular Biology

Structural basis for target-site selection in RNA-guided DNA transposition systems

Jung-Un Park, Amy Wei-Lun Tsai, Eshan Mehrotra, Michael T. Petassi, Shan-Chi Hsieh, Ailong Ke, Joseph E. Peters, Elizabeth H. Kellogg

The paper uses cryo-EM to reveal how TnsC regulates target-site selection in CRISPR-associated transposition systems by transferring polarity information to the transposase.

Science · Aug 12, 2021Peer-reviewedMolecular Biology