TMEM106B C-terminal fragments drive nucleocytoplasmic transport failure and TDP-43 mislocalization in the aging human brain
Kedamawit Tilahun, Janani Parameswaran, Myles Dudley, Daniel Pun, Fuying Ma, Jessee Zhang, Tatiana Olivia Bolds, Jie Jiang
This study shows that TMEM106B C-terminal fragments cause nucleocytoplasmic transport failure and TDP-43 mislocalization in aging brains, linking them to neurodegeneration.
bioRxiv · Apr 27, 2026 · PreprintNeuroscience