Kedamawit Tilahun

This study shows that TMEM106B C-terminal fragments cause nucleocytoplasmic transport failure and TDP-43 mislocalization in aging brains, linking them to neurodegeneration.

This study uses cross-species scRNA-seq to show that the 3q29 deletion causes mitochondrial dysfunction in both human cortical organoids and mouse models, suggesting a conserved metabolic disruption in schizophrenia.

This study identifies that antisense C4G2 repeat expanded RNAs, but not sense G4C2, activate the PKR/eIF2-dependent integrated stress response in C9orf72 FTD/ALS, leading to neuronal toxicity.