Perilysosomal Ca2+ overload impairs autophagic degradation in β-cell lipotoxicity
Ha Thu Nguyen, Luong Dai Ly, Thuy Thi Thanh Ngo, Soo Kyung Lee, Carlos Noriega Polo, Subo Lee, Taesic Lee, Seung‐Kuy Cha, Myung-Shik Lee, Andreas Wiederkehr, Claes B. Wollheim, Kyu‐Sang Park
This study shows that perilysosomal Ca2+ overload impairs autophagy in β-cells under lipotoxic stress, and restoring Ca2+ homeostasis can improve β-cell survival.
bioRxiv · Jan 27, 2025 · PreprintPhysiology