Claes B. Wollheim

Harnessing distinct tissue-resident immune niches via S100A9/TLR4 improves ketone, lipid, and glucose metabolism

This study shows that S100A9-TLR4 signaling in immune cells improves metabolic disorders by modulating immune niches in the liver and skeletal muscle.

Shedding of mitochondrial Voltage-Dependent Anion Channel-1 (VDAC1) Reflects COVID-19 Severity and Reveals Macrophage Dysfunction

This study shows that increased serum VDAC1 levels correlate with COVID-19 severity and macrophage dysfunction, suggesting VDAC1 as a biomarker and potential therapeutic target.

Perilysosomal Ca2+ overload impairs autophagic degradation in β-cell lipotoxicity

This study shows that perilysosomal Ca2+ overload impairs autophagy in β-cells under lipotoxic stress, and restoring Ca2+ homeostasis can improve β-cell survival.

Islet Gene View - a tool to facilitate islet research

The paper introduces Islet Gene View (IGW), a platform that integrates gene expression and phenotypic data from pancreatic islets to explore T2D-related gene expression changes and their functional implications.