mTOR-driven widespread exon skipping renders multifaceted gene regulation and proteome complexity
S. Cheng, N. A. Fahmi, M. Park, J.-W. Chang, J. Sun, K. Thao, H.-S. Yeh, W. Zhang, J. Yong
This study shows that mTOR hyperactivation causes widespread exon skipping, leading to diverse proteomic changes through alternative splicing in both 5’-UTR and coding regions.
bioRxiv · Feb 27, 2020Biochemistry