J. Yong

Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination

This study identifies non-neutralizing antibodies from vaccinated individuals that protect against SARS-CoV-2 in animal models, highlighting their role through Fc-mediated effector functions and conserved epitope binding.

Enzyme Bioink for the 3D Printing of Biocatalytic Materials

This paper develops a biocatalytic enzyme bioink for 3D printing that enhances the biochemical activity of printed constructs by covalently attaching horseradish peroxidase to a gelatin methacrylate scaffold.

Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption

The paper identifies lipid homeostasis as a regulator of proteostasis, showing that lipid dysregulation disrupts ESCRT function and causes lysosomal protein aggregation.

Constitutive, calcium-independent endoplasmic reticulum-plasma membrane contact site oscillations and its implications in store-operated calcium entry

This study investigates calcium-independent ER-PM contact site oscillations in RBL mast cells and their role in SOCE, showing PI(4)P dependency and the importance of reversible contact sites for calcium oscillations.

Ectopic FVIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma

This study shows that ectopic expression of misfolded BDD-FVIII in hepatocytes promotes hepatocellular carcinoma under high fat diet, independent of viral transduction.

mTOR-driven widespread exon skipping renders multifaceted gene regulation and proteome complexity

This study shows that mTOR hyperactivation causes widespread exon skipping, leading to diverse proteomic changes through alternative splicing in both 5’-UTR and coding regions.

Chop/Ddit3 depletion in β-cells alleviates ER stress and corrects hepatic steatosis

This study shows that deleting Chop/Ddit3 in β-cells reduces ER stress and corrects fatty liver disease in T2D without affecting glucose homeostasis.

Quantitative analysis and medium components optimizing for culturing a fastidious bacterium Christensenella minuta

This paper develops a quantitative method and optimizes culture conditions to significantly increase the biomass of the fastidious bacterium Christensenella minuta.

Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2+

The paper identifies a Ca2+-antagonized mechanism for ATP transport into the ER and links ER ATP usage to an anti-Warburg metabolic effect.