Development of potent dual BET/HDAC inhibitors via pharmacophore merging and structure-guided optimization
N. Bauer, D.-I. Balourdas, J. R. Schneider, X. Zhang, L. M. Berger, B.-T. Berger, N. A. Klopp, J. T. Siveke, S. Knapp, A. C. Joerger
This study develops potent dual BET/HDAC inhibitors through pharmacophore merging and structure-guided optimization, showing improved potency and efficacy in cancer cell models.
bioRxiv · Jul 18, 2023 · PreprintBiochemistry