Author

N. Arrighetti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Kentsis· 2 shared A. L. Kung· 2 shared D. Cameron· 2 shared E. De Stanchina· 2 shared F. S. Dela Cruz· 2 shared H. S. Mueller· 2 shared M. Gounder· 2 shared N. Zaffaroni· 2 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. Kentsis

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2 papers

Recent·Most cited

Epigenetic targeting of PGBD5-dependent DNA damage in SMARCB1-deficient sarcomas

Y. Kazansky, H. S. Mueller, D. Cameron, P. Demarest, N. Zaffaroni, N. Arrighetti, V. Zuco, P. S. Mundi, Y. Kuwahara, R. Somwar, R. Qu, A. Califano, E. De Stanchina, F. S. Dela Cruz, A. L. Kung, , A. Kentsis

The paper identifies ATR as a target for combination EZH2 epigenetic therapy in SMARCB1-deficient sarcomas, showing that EZH2 inhibition promotes DNA damage via PGBD5, and that ATR inhibition enhances therapeutic responses.

bioRxiv · May 3, 2024Cancer Biology

Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy

Y. Kazansky, D. Cameron, H. S. Mueller, P. Demarest, N. Zaffaroni, N. Arrighetti, V. Zuco, Y. Kuwahara, R. Somwar, M. Ladanyi, R. Qu, E. De Stanchina, F. S. Dela Cruz, A. L. Kung, M. Gounder, A. Kentsis

This study identifies mechanisms of resistance to EZH2 inhibition in SMARCB1-deficient cancers and proposes combination therapies to overcome resistance.

bioRxiv · Feb 6, 2023Cancer Biology