Arsenic trioxide resistance in acute promyelocytic leukemia: More to it than PML mutations
N. Balasundaram, S. Ganesan, E. Chendamarai, H. K. Palani, A. Venkatraman, A. A. Alex, S. David, S. Krishna, A. Korula, N. B. Janet, P. Balasubramanian, V. Mathews
This study identifies metabolic rewiring as a mechanism of arsenic trioxide resistance in APL and shows that combining ATO with mitocans can overcome resistance.
bioRxiv · Jun 21, 2020 · PreprintCancer Biology