Author

P. Balasubramanian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Assay:metabolomics· 2

Frequent Co-Authors

G. M. Diffee· 2 shared R. J. Colman· 2 shared S. R. Velayudhan· 2 shared A. A. Alex· 1 shared A. A. Pai· 1 shared A. Abraham· 1 shared A. B. Smith· 1 shared A. Bagchi· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

G. M. Diffee

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Author profile →

6 papers

Recent·Most cited

An unconventional mechanism of IL-1β secretion that requires Type I IFN in lupus monocytes

S. Caielli, P. Balasubramanian, J. Rodriguez-Alcazar, U. Balaji, Z. Wan, J. Baisch, C. Smitherman, L. Walters, P. Sparagana, D. Nehar-Belaid, R. Marches, L. Nassi, K. Stewart, J. Fuller, J. F. Banchereau, , V. Pascual

The paper identifies an unconventional IL-1β secretion mechanism in lupus monocytes requiring Type I IFN, involving mitochondrial RNA and the NLRP3 inflammasome.

bioRxiv · Aug 3, 2023 · PreprintImmunology

Mass spectrometry-based multi-omics identifies metabolic signatures of sarcopenia in rhesus monkey skeletal muscle

M. R. Pergande, K. J. Osterbauer, K. M. Buck, D. S. Roberts, N. N. Wood, P. Balasubramanian, M. W. Mann, K. Rossler, G. M. Diffee, R. J. Colman, R. M. Anderson, Y. Ge

This study uses mass spectrometry-based multi-omics to identify metabolic signatures of sarcopenia in rhesus monkey skeletal muscle, revealing age-related changes in energy metabolism and muscle function.

bioRxiv · Jul 31, 2023 · PreprintBiochemistry

Inhibition of BCR::ABL1 tyrosine kinase activity Aids in the Generation of Stable Chronic Myeloid Leukemia Induced Pluripotent Stem Cells

E. S. B. Benjamin, D. Babu, G. Joshi, B. M. Rajamani, K. Nandy, S. Rani, S. Anandhan, C. PremKumar, M. Maddali, A. Abraham, S. R. Velayudhan, P. Balasubramanian

This study generates stable CML-iPSCs by inhibiting BCR::ABL1 tyrosine kinase activity, enabling disease modeling and drug screening.

bioRxiv · Jun 1, 2023 · PreprintCancer Biology

Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies

V. Venkatesan, A. C. Christopher, P. Babu, M. K. K. Azhagiri, K. Walavalkar, B. Saravanan, S. Srinivasan, K. V. Karuppusamy, A. Jacob, S. Rangaraj, A. Bagchi, A. A. Pai, Y. Nakamura, P. Balasubramanian, R. Pai, , S. Thangavel

This study edits the PRR-βE1 region in HSPCs to suppress HbA and enhance HbF production, showing therapeutic benefits for β-hemoglobinopathies.

bioRxiv · Jul 11, 2022Biochemistry

Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice

P. Balasubramanian, A. E. Schaar, G. E. Gustafson, A. B. Smith, P. R. Howell, A. Greenman, S. Baum, R. J. Colman, D. W. Lamming, G. M. Diffee, R. Anderson

AdipoRon, an adiponectin receptor agonist, improves skeletal muscle function in aged mice by enhancing mitochondrial activity and metabolism, with effects observed in both mice and nonhuman primates.

bioRxiv · Sep 16, 2021Physiology

Arsenic trioxide resistance in acute promyelocytic leukemia: More to it than PML mutations

N. Balasundaram, S. Ganesan, E. Chendamarai, H. K. Palani, A. Venkatraman, A. A. Alex, S. David, S. Krishna, A. Korula, N. B. Janet, P. Balasubramanian, V. Mathews

This study identifies metabolic rewiring as a mechanism of arsenic trioxide resistance in APL and shows that combining ATO with mitocans can overcome resistance.

bioRxiv · Jun 21, 2020 · PreprintCancer Biology