Aggregatibacter actinomycetemcomitans LtxA hijacks endocytic trafficking pathways in human lymphocytes
E. Lally, K. Boesze-Battaglia, A. Dhingra, N. M. Gomez, C. H. Mitchell, A. Giannakakis, S. A. Fahim, R. Benz, N. Balashova
This study investigates how LtxA from Aggregatibacter actinomycetemcomitans enters and traffics within human lymphocytes, revealing its reliance on dynamin-dependent, clathrin-independent pathways and Rab5-mediated endocytic trafficking.
bioRxiv · Sep 14, 2019Microbiology