Disrupting myeloid-specific LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation
M. C. Gage, N. Becares-Salles, R. Louie, K. Waddington, Y. Zhang, T. Tittanegro, S. Rodriguez-Lorenzo, A. Jathanna, B. Pourcet, O. M. Pello, J. V. De la Rosa, A. Castrillo, I. Pineda Torra
This study shows that disrupting myeloid-specific LXRα phosphorylation increases FoxM1 expression and alters atherosclerosis by promoting macrophage proliferation and changing plaque composition.
bioRxiv · Dec 4, 2017Physiology