M. C. Gage

Macrophage-expressed Neuropilin 2 promotes plaque formation in ApoE knockout mice and is essential for pro-inflammatory macrophage polarisation and gene expression.

This study shows that macrophage-expressed Neuropilin 2 promotes atherosclerosis by enhancing pro-inflammatory polarization and plaque formation in ApoE knockout mice.

Metformin, empagliflozin and their combination modulate ex-vivo macrophage inflammatory gene expression

This study examines how metformin and empagliflozin affect macrophage inflammatory gene expression alone and in combination.

Aged insulin resistant macrophages reveal dysregulated cholesterol biosynthesis, a pro-inflammatory profile and reduced foam cell formation capacity

This study investigates how insulin resistance in aged macrophages affects inflammation, cholesterol biosynthesis, and foam cell formation, finding pro-inflammatory changes and reduced foam cell capacity.

Disrupting myeloid-specific LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation

This study shows that disrupting myeloid-specific LXRα phosphorylation increases FoxM1 expression and alters atherosclerosis by promoting macrophage proliferation and changing plaque composition.