Intra-membrane client recognition potentiates the chaperone functions of Calnexin
N. Bloemeke, K. Meighen-Berger, M. Hitzenberger, N. C. Bach, M. Parr, J. P. L. Coelho, D. Frishman, M. Zacharias, S. Sieber, M. J. Feige
This study shows that Calnexin uses its transmembrane domain to recognize and bind misfolded membrane proteins, enhancing its chaperone functions in the ER.
bioRxiv · Mar 7, 2022 · PreprintCell Biology